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What is meant by “genes at the trunk of the evolutionary tree”?

What is meant by “genes at the trunk of the evolutionary tree”?


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Recently I went through a paper about hepatocellular carcinoma in which they talked about trunk genes (p. 26, second paragraph):

Branching tumor evolution complicates efforts to implement personalized medicine and suggests that targeted therapies might be directed to genes that are mutated at the trunk of the evolutionary tree. Transposons provide powerful tools for identifying trunk genes, as insertions in trunk genes are more likely to be associated with a higher number of sequencing reads.

I really don't understand what are the trunk genes. Can anyone please explain them clearly.

Thank you


I think the article is using a phylogenetic tree to explain the stages of how the tumor has evolved.

According to Nature.com >>

All trees have a shared 'trunk', which represents the complement of mutations shared by all malignant cells within the cancer.

Or simplified by Britannica.com >>

Phylogenetic tree, also called Dendrogram, a diagram showing the evolutionary interrelations of a group of organisms derived from a common ancestral form. The ancestor is in the tree “trunk”; organisms that have arisen from it are placed at the ends of tree “branches.”

For a visual representation, this is a phylogenetic tree for evolution of breast cancer >>

Image Source: Phylogenetic Cancer Trees


Watch the video: Τα γονίδια και η κληρονομικότητα (September 2022).


Comments:

  1. Jasper

    I'm sorry, this is not exactly what I need. Who else can suggest?

  2. Shall

    That he projects?

  3. Daishura

    On your place I would arrive differently.

  4. Mira

    you can tell, this exception :)

  5. Drayce

    Ugh, you bullshit!

  6. Wichell

    The trifles!

  7. Sarsour

    What words ... Great, a brilliant phrase

  8. Mikael

    Just a great idea visited you



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