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Advanced books about molecular biology and genetics

Advanced books about molecular biology and genetics


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I'm finishing my third year of biochemistry and doing gene therapy practicals during the summer. I'd like to buy a book that describes flow of genetic information (transcription, translation, replication, splicing… ) and its mechanisms in depth (such as transcription factors, regulation, etc). The closest thing I currently own is Lehninger's Principles of Biochemistry, but most of it deals with metabolism. I've also got to know about Molecular Biology of the Gene, but I'm not sure if it's what I'm looking for. I'm not interested in books about heredity or population genetics.


Molecular Biology of the Cell is a great text book, and an older edition is available for free on NCBI bookshelf. However, the book covers a broader range of topics than perhaps you're interested in and may not go into the same depth as others (though I haven't actually done a side-by-side comparison).

Watson, who along with Crick developed the central dogma of molecular biology, literally wrote the book on this subject: Molecular Biology of the Gene. It sounds exactly like the text book you're looking for, and was one of my favourites as an undergrad. You can check out the contents of the book yourself to make sure it's what you want.


The classic, "The molecular biology of the cell" https://en.wikipedia.org/wiki/Molecular_Biology_of_the_Cell_(textbook) helped me a great deal… 30 years ago. It has been continually updated and is the best source I know. However, books take years to write, and are therefore always years behind. With answers to every imaginable question on the internet, why limit yourself to books?


Cell Biology, Genetics, Molecular Biology, Evolution and Ecology

The revised edition of this bestselling textbook provides latest and detailed account of vital topics in biology, namely, Cell Biology, Genetics, Molecular Biology, Evolution, and Ecology. The treatment is very exhaustive as the book devotes exclusive parts to each topic, yet in a simple, lucid and concise manner. Simplified and well-labeled diagrams and pictures make the subject interesting and easy to understand. It is developed for students of B.Sc. Pass and Honours courses, primarily. However, it is equally useful for students of M.Sc. Zoology, Botany and Biosciences. Aspirants of medical entrance and civil services examinations would also find the book extremely useful.

Key Features :
• Discussion on new topics such as Genetic Engineering (Biotechnology) and Immunology added
• Over 700+ figures and images for effective understanding of the concepts
• Over 600+ revision questions to help students evaluate their knowledge

Cell Biology
• Introduction • Techniques in Cell Biology • Cell • Cytoplasmic Matrix (Chemical Organization of the Cell) • Plasma Membrane and Cell Wall • Endoplasmic Reticulum (ER) • Golgi Apparatus • Lysosomes • Microbodies: Peroxisomes and Glyoxysomes • Mitochondria • Plastids (Chloroplasts, Photosynthesis and Vacuoles) • Nucleus • Chromosomes • Ribosomes • Cytoskeleton: Microtubules, Microfilaments and Intermediate Filaments • Centrioles and Basal Bodies • Cilia and Flagella • Cell Growth and Cell Division (Cell Cycle, Mitosis and Meiosis) • Reproduction • Gametogenesis • Fertilization • Parthenogenesis • Growth

Genetics
• Introduction • Genetical Terminology • Mendel and His Work • Genetic Interaction and Lethal Genes • Quantitative Genetics (Inheritance of Multiple Genes) • Inbreeding, Outbreeding and Hybrid Vigour • Linkage • Crossing Over • Genetic and Cytological Mapping of Chromosomes • Multiple Alleles • Fine Structure of Gene • Sex-linked Inheritance • Determination of Sex and Sex Differentiation • Chromosomal Mutation-I (Cytogenetics: Changes in Structure of Chromosome) • Chromosomal Mutation-II (Cytogenetics: Changes in Chromosome Number) • Gene Mutation • Cytoplasmic or Extra-Nuclear Inheritance • Human Genetics • Eugenics, Euphenics and Genetic Engineering • Transposable Genetic Elements (Jumping or Mobile Genes)

Molecular Biology
• Introduction • Identification of the Genetic Materials • Chemical Nature of Genetic Materials (i.e., DNA and RNA) • Replication of DNA • Non-genetic Ribonucleic Acid (RNA and Transcription) • Genetic Code • Protein Synthesis • Regulation of Gene Action • Genetic Engineering (Isolation, Sequencing, Synthesis of Gene and DNA Fingerprinting) • Immunology • Genetic Recombination and Gene Transfer (Bacterial Conjugation, Transformation, Transduction, Episomes and Plasmids)

Evolution
• Introduction • Development of the Idea of Organic Evolution • Direct Evidences of Evolution: Fossils • Indirect Evidences of Evolution • Theories of Organic Evolution (Lamarckism, Darwinism, Modern Synthetic Theory, Germplasm Theory and Mutation Theory) • Selection in Action (Examples and Types of Natural Selection) • Population Genetics and Evolution • Evolution above Species Level (Adaptation, Adaptive Radiation, Microevolution, Macroevolution, Mega evolution, Punctuated Equilibria and Related Phenomena) • Isolation • Speciation • Barriers • Origin of Life

Ecology
• Introduction • Ecology in India • Environment • Abiotic Environmental Factors • Biotic Environmental Factors • Population (Population Ecology) • Biotic Communities (Community Ecology: Communities, Niche and Bio-Indicators) • Ecological Succession • Ecosystem: Structure and Function • Biogeochemical Cycles • Aquatic Ecosystems: Freshwater Communities • Aquatic Ecosystems: Estuaries and Marine Communities • Terrestrial Ecosystems • Pollution (Environmental Pollutants and Toxicology) • Ecology and Human Welfare (Natural Resource Ecology: Natural Resources, Conservation and Management) • Wild Life Management • Biogeography (Distribution of Animals and Plants) • Adaptations (Aquatic Adaptations, Volant Adaptations and Desert Adaptations) • Indices

Click on the below link to view the book Cell Biology, Genetics, Molecular Biology, Evolution and Ecology by Verma and Agarwal:

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Advanced books about molecular biology and genetics - Biology

The aspergilli are a fascinating group of fungi exhibiting immense ecological and metabolic diversity. These include notorious pathogens such as Aspergillus flavus, which produces aflatoxin, one of the most potent, naturally occurring, compounds known to man. Conversely, also included are other fungi, such as A. oryzae, involved in the industrial production of soy sauce and sake or A. niger used for the production of citric acid and enzymes such as glucose oxidase and lysozyme. Such is the interest in Aspergillus that, to date, the sequences of fifteen different Aspergillus genomes have been determined providing scientists with an exciting resource to improve the understanding of Aspergillus molecular genomics and act as a spring board for mining for new metabolites and novel genes of industrial or medical importance.

In this book leading Aspergillus researchers review and summarise the most important aspects of Aspergillus molecular biology and genomics. The book opens with a fascinating overview of the genus Aspergillus. This is followed by in-depth reviews of the Aspergillus molecular systematics, comparative genomics, bioinformatics and systems biology of Aspergillus, transcriptional regulation, genetics and genomics of sexual development of A. nidulans, genomics and secondary metabolism, ecology, development and gene regulation in A. flavus, functional systems biology, and novel industrial applications of A. oryzae genomics.

Essential reading for everyone with an interest in Aspergillus and related fungi.

"This volume is essential reading for anyone interested in Aspergillus and related fungi." from SciTech Book News

". (a) feast of hugely topical science . This book presents a modern-day dictionary of all things Aspergillus. It is highly readable and has been considerately crafted in terms of structure. From the very first chapter a sense of excitement about the new opportunities afforded by this fascinating genus is derived, which extends far beyond the interests of any single researcher but succeeds in capturing the relevance of genus-based findings for all who work with aspergilli. The essence of functional genomics and systems biology therefore permeates the volume, and ultimately the readers psyche. Not only does it provide a concise and highly current overview of Aspergillus genomics, it also manages to archive decades of relevant and highly insightful biology in a portable format. The book is a must-read for anyone whose work or study involves any member(s) of the Aspergillus genus. I, certainly, will be consulting it daily for a long time to come." from Biotechnology (March 2010)

". an overview of the forefront of Aspergillus genomics - from bioinformatics and systems biology to gene regulation, secondary metabolism, and novel industrial applications . (the book starts) with a superb holistic overview of the genus by its doyenne Joan Bennett . a most stimulating volume . The editors and publishers can be proud of having put together a volume that is produced to the highest scientific standards." from Mycological Research 113: 1444-1445

"a thorough review of recent research in the genetics of Aspergillus . It has information on Aspergillus species that is difficult to find in other sources." from Doodys

"a readable but authoritive overview . This book will be a good institutional purchase to support advanced teaching but also for personal or laboratory purchase for researchers within industry." from Microbiology Today

"a nice compact book full of detailed information . should be available in university libraries and colleges where genomics is taught" from Fungal Diversity (2010) 45: 345-356

(EAN: 9781904455530 9781912530892 Subjects: [microbiology] [medical microbiology] [molecular microbiology] [genomics] [mycology] )


Activities and assessment solutions for students in advanced molecular genetics and biochemistry to direct and engage with public communication in an online environment

Kimberly L. Kanapeckas Métris, Department of Genetics & Biochemistry, Clemson University, 157 Poole Agricultural Center, 130 McGinty Court, Clemson, SC 29634-0318.

Department of Genetics & Biochemistry, Clemson University, Clemson, South Carolina, USA

Kimberly L. Kanapeckas Métris, Department of Genetics & Biochemistry, Clemson University, 157 Poole Agricultural Center, 130 McGinty Court, Clemson, SC 29634-0318.

Abstract

Apart from classroom presentations to their instructors and peer groups, STEM students have limited opportunities or encouragement to engage in guided communication of scientific concepts to others (family, friends, or the general public). A critical need exists for accurate, comprehensible science to be disseminated to these groups. To develop student proficiency in communication of complex biomolecular concepts impacting diverse audiences, I introduce learning approaches and assessments easily adapted to fit the needs of individual instructors and any molecular biology or biochemistry laboratory or lecture course in a remote/online environment. To help students develop an appreciation of the needs of different audiences and the nuanced drivers of clear communication, I provided them the choice of projects of similar length: Option (1) Create a scientific news release and short podcast or video clip newscast describing a recent advancement in understanding the molecular/biochemical basis of a disease or Option (2) Create a lesson plan and mini-video designed to teach a simple biochemical or molecular mechanism of disease with learning objectives, a brief activity, and appropriate assessment mechanisms. Students who chose the scientific news release/newscast activity distilled complex biomolecular concepts using the 5 W's of journalism—who, what, where, why, when—and learned to accurately communicate the relevance of advanced scientific discoveries and recent events for a broader audience. Students who chose the lesson plan designed activities centered on biomolecular science concepts that build upon what their audience already knows, revealing possibilities for undergraduates to contribute to educational outreach to secondary school teachers and classes.

Appendix S1: Supporting information.

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


  • I. Reference Information
  • II. The Process of Science
  • III. Themes and Concepts of Biology
  • IV. Cell Structure and Function
  • V. Membranes and movement of molecules
  • VI. Enzyme-catalyzed reactions
  • VII. How cells obtain energy
  • VIII. Photosynthesis

BI102: Survey of Molecular Life and Genetics is intended for one term of the introductory biology course for non-science majors taught at many two- and four-year colleges. The concepts of genetics, as they apply to the study of life, are introduced, including the principles of inheritance, genetics, and gene regulation.

This textbook incorporates the mandates found in Vision and Change and focuses on the non-content aspects of biology education that are just as important. Additionally, this book explicitly teaches the general education outcomes that we have identified as important for this class. This textbook pulls together biology content resources that are accessible for our community college non-major biology students, as well as resources to provide them with explicit instruction in the quantitative literacy, communication, and information literacy general education outcomes as they relate to the biology content they are learning.


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The goal of the branch is to demonstrate that research findings and opportunities derived from genetic and genomic technologies may be translated into improved diagnosis, treatments and prevention of human diseases. Using the excellent resources of NHGRI intramural laboratories, the NIH Clinical Center and intramural collaborations across NIH, the branch is engaged in basic, translational and clinical research, bringing the latest genomic and genetic technologies to the study of human disease.

Our investigators develop and quickly evaluate novel translational approaches and advanced technologies. In addition, collaborations with the NIH Clinical Center, the NIH Intramural Sequencing Center and the NIH Chemical Genomics Center support projects that expand the breadth of single-investigator laboratories. The NHGRI core facilities are equally important components of all branch research efforts, giving our investigators access to state-of-the-art bioinformatic, transgenic-animal, flow-cytometry, genomic and cytogenetic technologies. These resources have allowed our investigators to develop clinical trials for gene therapy of immune deficiency and preclinical development of gene therapy for metabolic disorders. In addition, our investigators have discovered disease genes and identified small molecules to treat inherited diseases and malignancies.

Mentorship and preparation of trainees for their future careers is a priority for the branch. Branch faculty provide a broad-based learning experience for trainees that is extended and integrated with the NHGRI and NIH intramural training and seminar programs. Our investigators participate in outreach activities and learning opportunities, provide summer internships and mentor students from underrepresented groups

The goal of the branch is to demonstrate that research findings and opportunities derived from genetic and genomic technologies may be translated into improved diagnosis, treatments and prevention of human diseases. Using the excellent resources of NHGRI intramural laboratories, the NIH Clinical Center and intramural collaborations across NIH, the branch is engaged in basic, translational and clinical research, bringing the latest genomic and genetic technologies to the study of human disease.

Our investigators develop and quickly evaluate novel translational approaches and advanced technologies. In addition, collaborations with the NIH Clinical Center, the NIH Intramural Sequencing Center and the NIH Chemical Genomics Center support projects that expand the breadth of single-investigator laboratories. The NHGRI core facilities are equally important components of all branch research efforts, giving our investigators access to state-of-the-art bioinformatic, transgenic-animal, flow-cytometry, genomic and cytogenetic technologies. These resources have allowed our investigators to develop clinical trials for gene therapy of immune deficiency and preclinical development of gene therapy for metabolic disorders. In addition, our investigators have discovered disease genes and identified small molecules to treat inherited diseases and malignancies.

Mentorship and preparation of trainees for their future careers is a priority for the branch. Branch faculty provide a broad-based learning experience for trainees that is extended and integrated with the NHGRI and NIH intramural training and seminar programs. Our investigators participate in outreach activities and learning opportunities, provide summer internships and mentor students from underrepresented groups


Biology: Cellular, Molecular Biology, and Genetics Concentration, B.S.

* Course credit hours only count once toward the total university graduation credit hour requirements. Click on Credit Sharing   for more information.

Major Requirements (38-39 Credits)

Complete the following courses:

Additional courses: (26-27 Credits)

Students are required to take an additional 26-27 credits as noted below. Following completion of BIOL 121   and BIOL 122   , students need to select one of the following three concentrations in accordance with their career goals with assistance from their academic advisers.

A grade of ‘C’ or better is required in all major requirements, BIOL 121   /BIOL 121L   , BIOL 122   /BIOL 122L   , and additional biology electives. All biology electives must be selected from 300-400 level courses offered by the Department of Biology (prefix BIOL), except that a student may take up to eight credit hours of coursework from biology related courses offered by other departments (prefix other than BIOL) toward his/her biology electives.


Molecular Biology of Human Cancers

Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer.

Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis.

A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point.

In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III.

More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.

"Although Molecular Biology of Human Cancers is intended as a text for a graduate-level course, it is even more valuable for researchers like me, as a thoughtful encapsulation of the important areas of contemporary cancer research. … the book is well designed as a text. The prose is clear, the numerous diagrams and tables are helpful … . is unique in both coverage and perspective. Overall, I know of no other single source that provides a thoughtful view of more areas of molecular cancer research." (Joseph Locker, Angiogenesis, Vol. 7, 2004)

"This is a detailed and comprehensive review of the molecular aspects of cancer aetiology and development in man. It is aimed at advanced students and trainees in cancer-related disciplines and thus at a rather broad-spectrum audience. … Overall, this is an interesting and informative book, which would be helpful to students wishing to have some in-depth knowledge of cancer genetics, and an overview of general concepts in this field … ." (Shirley Hodgson, Human Genetics, Vol. 123, 2008)


Individual Clinical Projects and Papers

You will be introduced to the relationship between the world of the laboratory and the world of the clinic through an individual project. To carry out this project we will introduce you to a clinician-researcher who will serve as your mentor and contact point. The specific goal of this project is to provide you with a first hand view of the issues and experiences which occur as modern molecular biology meets the world of individual experience from the perspective of the patient and the family. You will be expected to meet with patients and family members either in the context of the clinician's activities or individually through contacts made for you by the clinician. However, you are expected to go beyond simply following the clinician in his or her patient contact. Your paper should synthesize the research and clinical implications of the genetics and molecular biology underpinning the disease.

The choice of focus for your individual project and paper is one that we want you to resolve as soon as possible. We will circulate a list of possible mentors and topics. Once you have been assigned a topic, you will be responsible for contacting your clinical mentor and arranging a meeting. This should be done as early in the term as possible. We know that you have busy schedules, but the clinicians are busier than you are. You will have to work around their schedules, so do not wait until the last minute to initiate your project.


Watch the video: Bruce Alberts UCSF: Learning from Failure (October 2022).